Vellore district is bounded on the north by the Chittoor district (Andhra Pradesh) and a portion of Tiruvallur district and on the south by the Tiruvannamalai district. On the west are the districts of Dharmapuri and Chittoor (Andhra Pradesh) while Kanchipuram, Tiruvallur and Tiruvannamalai districts are in its eastern boundary. Vellore district is in the inland region and is of irregular shape. Headquarters of this district is Vellore.

Vellore city lies along the Palar River, southwest of Chennai. Vellore is now pursuing with activity as a commercial, administrative and medical center. Vellore is renowned for a Christian Medical College and Hospital, which attracts patients and research scholars from all corners. The people who come here from all over India for medical care gives this humble town a cosmopolitan feel. For tourists, it is noteworthy only for the Vijayanagar fort and its temple, which are in an excellent state of preservation and worth visiting.